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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salas, Armando | SP | Hickory Crazies | 27 | 02/16/1997 | Hostos | DOM | Switch | Right | 5' 9" | 175 lbs | - |
| Salazar, David | SS | Charleston Capitals | 20 | 06/11/2003 | Ames | USA | Left | Right | 5' 11" | 170 lbs | - |
| Salazar, Emílio | C | Greenville Emeralds | 23 | 01/27/2001 | Santo Domingo | DOM | Right | Right | 6' 1" | 195 lbs | - |
| Salazar, Pedro | 1B | West Virginia Jethros | 23 | 06/28/2000 | Catia La Mar | VEN | Right | Right | 6' 6" | 205 lbs | - |
| Saldana, Mario | 2B | West Virginia Jethros | 23 | 05/09/2001 | Stockton | USA | Right | Right | 6' 0" | 190 lbs | - |
| Salinas, Salvador | 2B | Hagerstown Sockeyes | 24 | 03/06/2000 | San Juan | PUR | Right | Right | 6' 1" | 190 lbs | - |
| Sanchez, Roberto | SS | Lexington Flying Eagles | 21 | 04/21/2003 | San Mateo | VEN | Right | Right | 6' 0" | 170 lbs | - |
| Saucedo, Manuel | 1B | Savannah Sky Chiefs | 21 | 10/27/2002 | Santo Domingo | DOM | Switch | Right | 6' 2" | 190 lbs | - |
| Sele, Gunner | RP | Augusta Atlantics | 22 | 06/08/2001 | Dalton Gardens | USA | Left | Left | 6' 1" | 175 lbs | - |
| Shepard, Dennis | RF | Greenville Emeralds | 21 | 10/31/2002 | Redding | USA | Right | Right | 6' 2" | 185 lbs | - |
| Shepherd, Daniel | RP | Kannapolis Gaels | 19 | 09/16/2004 | Yorketown | USA | Right | Right | 6' 0" | 175 lbs | - |
| Silva, Ronaldo | 3B | Hagerstown Sockeyes | 23 | 10/12/2000 | San Pedro de Macorís | DOM | Right | Right | 6' 0" | 180 lbs | - |
| Singleton, Ben | CF | Greensboro Sidewinders | 23 | 11/20/2000 | Midland | USA | Right | Right | 5' 9" | 185 lbs | - |
| Smith, Lawrence | SS | Lexington Flying Eagles | 22 | 11/26/2001 | Minerva | USA | Right | Right | 5' 10" | 170 lbs | - |
| Solís, Roberto | RF | Greensboro Sidewinders | 23 | 04/21/2001 | Pink | USA | Left | Left | 5' 11" | 180 lbs | - |
| Soriano, Daniel | SP | Lexington Flying Eagles | 21 | 02/05/2003 | Guatire | VEN | Switch | Left | 6' 4" | 195 lbs | - |
| Souza, Pedro | RP | Savannah Sky Chiefs | 26 | 11/25/1997 | Asheboro | USA | Left | Left | 5' 10" | 195 lbs | - |
| Spears, John | SP | Savannah Sky Chiefs | 23 | 08/28/2000 | Metairie | USA | Left | Left | 6' 5" | 200 lbs | - |
| Stanton, Mike | RP | Hickory Crazies | 27 | 06/23/1996 | Dublin | USA | Right | Right | 6' 4" | 205 lbs | - |
| Starr, Harold | SS | Greensboro Sidewinders | 22 | 12/29/2001 | Greensboro | USA | Right | Right | 6' 4" | 195 lbs | - |
| Stephenson, Kevin | SP | Hagerstown Sockeyes | 24 | 09/26/1999 | Ft. Bragg | USA | Right | Left | 6' 1" | 180 lbs | - |
| Stewart, Tim | SP | West Virginia Jethros | 27 | 09/19/1996 | Lakewood | USA | Left | Right | 5' 10" | 190 lbs | - |
| Stotzky, Max | RF | Hagerstown Sockeyes | 24 | 11/13/1999 | Huntington | USA | Right | Right | 6' 1" | 190 lbs | - |
| Sullivan, Spike | RP | Free Agent | 28 | 04/05/1996 | Durham | USA | Right | Right | 6' 0" | 195 lbs | - |
| Sutton, Ralph | 1B | Kannapolis Gaels | 20 | 09/17/2003 | Boca Raton | USA | Right | Right | 6' 2" | 200 lbs | - |
| Swanson, Justin | RP | Charleston Capitals | 20 | 10/20/2003 | Casper | USA | Left | Right | 5' 9" | 165 lbs | - |
| Sánchez, Carlos | LF | Hagerstown Sockeyes | 21 | 07/04/2002 | Santo Domingo | DOM | Right | Right | 6' 4" | 200 lbs | - |
| Sánchez, José | RP | Rome Wild Riders | 21 | 11/04/2002 | Ocumare del Tuy | VEN | Right | Right | 6' 3" | 195 lbs | - |
| Sánchez, José | SP | Rome Wild Riders | 23 | 02/19/2001 | Santo Domingo | DOM | Left | Right | 6' 9" | 205 lbs | - |
